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Pathogenesis of Severe Asthma
AbstractPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidence point to the fact that severe asthma is not a single phenotype. Cluster analyses have identified subclasses of severe asthma using parameters such as patient characteristics, and cytokine profiles have also been useful in classifying moderate and severe asthma.The IL‐4/IL‐13 signaling pathway accounts for the symptoms experienced by a subset of severe asthmatics with allergen‐associated symptoms and high...
Published By: MedWorm - Wednesday, 22 February