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Cysteinyl Leukotriene Receptors, Old and New; Implications for Asthma
AbstractThe cysteinyl leukotrienes (cys‐LTs) are three structurally similar but functionally distinct lipid mediators of inflammation. The parent cys‐LT, LTC4, is synthesized by and released from mast cells, eosinophils, basophils, and macrophages, and is converted to the potent constrictor LTD4 and the stable metabolite, LTE4. While only two cys‐LT‐selective receptors (CysLTRs) have been identified, cloned, and characterized, studies dating back three decades predicted the existence of at least three functional CysLTRs, each with a characteristic physiologic function in airways and other tissues. The recent demonstration that mice lacking both known CysLTRs...
Published By: MedWorm - Wednesday, 22 February